个体化用药基因检测-十堰太和医院.PPT

Human Genome Project research showed that 99.9 percent of individual genes is the same, but there are sequences in a very small (0.1 percent) of genetic differences, which mainly were SNPs. SNPs (single nucleotide polymorphism) most commonly refer to single-base differences in DNA among individuals. Polymorphisms are usually defined as sites where the less allele has a frequency of at least 1% in the population. SNPs present in the entire human genome, may be each 100-300bp existed a SNP, estimated that the total number in the millions, but for some purposes rarer variants are important as we