蛋白类抗凝血药物的研究进展.pdfVIP

现代药物与临床 Drugs Clinic 第 27 卷 第 5 期 2012 年 9 月 • 503 • 蛋白类抗凝血药物的研究进展 1,2 1 1 1* 曹政红 ，付 刚 ，龚 珉 ，徐为人 1. 天津药物研究院 天津市新药设计与发现重点实验室，天津 300193 2. 天津中医药大学，天津 300193 摘 要：血栓性疾病包含血栓形成和血栓栓塞所引起的疾病，又称血栓栓塞性疾病，是人类常见的多发病，严重危害人类的 健康，是现代社会主要的致死性疾病之一。抗凝血药物是通过影响凝血过程中的某些影响因子来阻止血液凝固，从而起到预 防与治疗血栓栓塞性疾病的作用。多肽等蛋白类抗凝血药见效快、不良反应小，是今后抗凝药研究的重点。对抗凝血多肽等 蛋白类抗凝药物进行了评述。 关键词：血栓；抗凝血；凝血机制；多肽 中图分类号：R973 文献标志码：A 文章编号：1674 - 5515(2012)05 - 0503 - 04 Research progress in protein anticoagulants 1, 2 1 1 1 CAO Zheng-hong , FU Gang , GONG Min , XU Wei-ren 1. Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China 2. Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China Abstract: Thrombotic disease,caused by thrombosis and thromboembolism, was also called thromboembolic disease, which is a common frequently-occurring disease. It is seriously harmful to human health and is one of the major causes of death in modern society. Anticoagulant drugs prevent blood clotting by influencing some impact factors in the blood coagulation process, and play an important role in prevention and treatment of the thromboembolic disease. Biological anticoagulant drugs, for example polypeptide, which have many advantages such as taking quickly effect but low side effects, are mostly becoming the emphasis in the study on anticoagulants. In this paper, several anticoagulant polypeptides and biological kinds of anticoagulation drugs have been reviewed. Key words: thrombus; anticoagulation; clotting mechanism; polypeptides 血液成分流动过程中在血管或心脏内膜表面形 测，低相对分子质量肝素是静脉注射制剂，华法林 成的一种半凝块状物质即为血栓，血栓病是由血栓 起效慢、疗效波动大等原因使得有必要进一步研发 引起的血管腔狭窄与闭塞，使主要脏器发生缺血和