氮-酰基保护的含氮化合物的不对称碳氢烯基化-天然药物化学专业毕业论文.docx

3．2结果与讨论 3．2结果与讨论 60 3．2．1反应条件的探索 60 3．2．2底物的拓展 ．63 3．2．3机理研究 ．64 3．3实验操作 66 3．3．1底物的合成 ．66 3．3．2氮酰基保护的四氢．13．咔啉的不对称碳氢烯基化 ．66 3．4化合物绝对构型的确定 67 3．5合成应用 68 3．6化合物表征数据 69 3．7小结 82 参考文献 ．83 第4章氮酰基保护的四氢吡啶的不对称碳氢烯基化 ． ．85 4．1研究背景 85 4．2结果与讨论 85 4．2．1条件的筛选 ．86 4．2．2底物的拓展 ．88 4．3实验操作 90 4．3．1底物的合成 ．90 4．3．2氮酰基保护的四氢吡啶的不对称碳氢烯基化 ．．91 4．4产物绝对构型的确定 91 4．5化合物表征数据 93 4．6／J、结 ．108 参考文献 109 致{射 1 1 l 发表文章目录 一112 附录：化合物谱图 一1 13 核磁谱图 113 液相谱图 192 万方数据 Abstract Abstract l Abstract．．． ．．． ． ． ．．．．．． ．．．．．．．．． ． ．． ． ．． ． ．．。． ． ．．．．．．．4 Symbolic Description．．．．．．． ．．．． ．．． ．．． ． ． ．． ．．．． 7 Chapter 1 Introduction．．．．． ．．．．．．．．．．． ．．．． ．．． ．．．． ．．．．．．．．．．． ．．．．．． ． ．．．．．．．． ．．． ．．．．．．．8 1．1 Preface ．8 1．2 Traditional approachs ofasymmetric synthesis ofTHIQs ．．8 1．3 Asymmetric C-H functionalization ofTHIQs ．1 l 1．4 Asymmetric synthesis ofTHCs 18 1．5 Asymmetric synthesis oftetrahydropyridines ．22 1．6 Conclusion ．26 Reference 27 Chapter 2 Asymmetric C-H vinylation ofN-acyl THIQs．． ．．．．．． ．．． ． ．．．．．．．．．．．． ．32 2．1 Research background ．．32 2．：!Design of the project 35 2．3 Experiment result and discussion 36 2．3．1 Optimization ofreaction conditions 36 2．3．2 The scope of substrates ．．39 2，3．3 Mechansim studies ．． ． ．．．．．． ． ． ．．．．．．．．．．． ． ，．．．．．． 40 2，4 Experiment．．． ．． ． ．．．．．．． ．．．．． ．． ．．． ．．．． ．．．．．．． ．．．．．．．．．．． ．43 2．4．1 General procedure for the synthesis ofsubstrates ．．43 2．4．2 General procedure for the synthesis ofboronates ．．44 2．4．3 General procedure for the synthesis of catalyst． ． ．．．．．．．．．．． ．．．．．．．．．． 44 2．4．4 Asymmetric C-H vinylation ofN-acyl THIQs ．45 2。5 Spectrum data．。．． ．。。．．．。。．． ．．．。。．．．．．．．．．．．。。．．．．．． ．． ．． ．．．．．．．．．．． ．．．。．．．．． 46 2．6 Conclusicln ．57 Reference ．．． ． ．．．．， ．．． ．．．．，．．．．． ．．．，，．．．．． ． ． ． ．．．．．．．．． ．58 Chapter 3 Asymmetric C-H vinylation ofN-acyl THCs ．60 3．1 Research background ．．60 万方数据 3．2 3．2 Experiment result and discussion．． ．．．．