新型磷酸二酯酶5抑制剂Avanafil的合成分析.pdfVIP

ABSTRACT Male erectile dysfunction is a prevalent problem. There are many men suffering from different extent of ED problems. PDE 5 is a member of PDE families，which exists widly in corpus cavernosum smooth muscle. PDE 5 inhibitor is responsible for the relaxation or contraction of corpus cavernosum smooth muscle through regulation cGMP and cAMP. Avanafil is a PDE 5 inhibitor, is used for the treatment of male erectile dysfunction. The synthetic rout of avanafil was de