转基因治病模型.pptVIP

Transgenic Mutation Animal Assays转基因动物致突变模型 Outline 概要 Introduction Transgenic mutation systems Development of transgenic mutation animals Protocol for transgenic mutation assays Validation of transgenic mutation assays Comparison of mutations in transgenes and native genes Transgenic mutation assays vs. other genotoxic assays, and vs. carcinogenicity assays Use of transgenic animal mutation assays Regulatory use for in vivo genotoxicity testing Mechanistic studies Conclusion Introduction 导言 What is Mutation? 什么是突变？ Mutations are heritable changes in the nucleotide sequence of DNA M