肺癌个体化精准治疗.pptx

New Horizon Advance;;其中肺癌治疗的疗效差别也较大;;;已发现众多肺癌相关分子但？ ;基因水平突变;肺癌治疗是复杂的系统工程;肺癌治疗方案选择 疗效评价=Survival;Local Control;Quality ;;肺癌个体化治疗之策略; 治疗与相关分子靶点关系;Potential Interactions between SBRT Target drugs;RECEL Results: Cut-off 2015/05/31;个体医学分子靶向治疗新模式;肺癌个体化治疗理念和实践; 个体化全程管理与排兵布阵 首先要确定治疗目的或目标;;放化疗与免疫联合:New Paradigm;免疫指标CD8+TILs预测PFS和OS;过度放化疗破坏机体免疫;Check-point Signaling in Ca Immunotherapy;Check Mate-017 057;;晚期NSCLC: Success or Not;;SBRT;可手术I期NSCLC: SBRT Vs 手术STARS ROSEL Pooled Analysis of 58 pts;; 放射免疫治疗:远隔效应 ;单纯放疗对区域淋巴结及远隔效应影响研究;不同分割模式放疗对肿瘤的局控率不同，引发的免疫反应也不同，但均未见明显的远隔效应 大分割较常规分割对肿瘤的局控率更高，进一步激活局部肿瘤、引流淋巴结及全身免疫反应;Local plus Systemic Control Lead to Ca Cure;Bernstein and Chang. Nature Rev Clin Onco;Phase III Trial-Study Design;Not All Stage IV Lung Cancer Are Equal ;Can Stage IV Lung Ca: Have 5 yr OS? Yes ; 免疫与靶向之比较;个性化治疗方案;;;Dear? Shuanghu Yuan, MD, PhD, ? On behalf of the?Annual Meeting Scientific Program Committee?of the American Society for Radiation Oncology, I am pleased to inform you that you have been selected as one of the recipients of a 2015 Annual Meeting Abstract Award.? You have won the?International Abstract Award?for your abstract titled,?“Noninvasive Evaluation of Metabolic Tumor Volume in LLC Tumor Bearing C57 Mice With PET and the Radiotracers 18F-Alfatide and 18F-FDG: A Comparative Analysis.” ? To honor your achievement, you will receive a?$4,000?award and a?complimentary registration?to the Annual Meeting.? All award winners will be featured in the Annual Meeting Proceedings and in the Final Program, and you will be given a Certificate onsite at the meeting during the International Breakfast.?Your attendance at the meeting is required in order to receive the award benefits.??Your award check will be available for pick-up at the Faculty/VIP office at the Henry B. Gonzalez Convention Center when you arrive in San Antonio. ? The Annual Meeting dates are:? October 17 – 21, 2015 Location:? Henry B. Gonzalez Convention Center, Sa