杂环化合物的反应.pptVIP

六员杂环化合物的芳香C-H键反应一般发生在α位。 3.芳香C-H键反应 A）Chichibabin氨化 ANRORC (Add. Of Nu., Ring Opening and Ring Closure) B. VNS氨化 C. 格氏试剂反应 D. 重氮化 1. ANRORC mechanism The ANRORC mechanism in organic chemistry describes a special type of substitution reaction. ANRORC stands for Addition of the Nucleophile, Ring Opening, and Ring Closure in nucleophilic attack on ring systems and it helps to explain product formation and distribution in some nucleophilic substitutions especially in heterocyclic compounds. This reaction mechanism has been extensively studied in reactions of metal amide nucleophiles (such as