anwsers of Exercise_1(1)医学遗传学训练.docVIP

Exercise 1 TRUE/FALSE 1. __T__ An autosomal（常染色的） locus with 8 alleles has 28 heterozygotes（杂合体）.(a1,a2,a3,a4,a5,a6,a7,a8; 7+6+5+4+3+2+1=28) 2._F__ The more the chromosome interference the more recombination frequency underestimates map distance.(the more the chromosome interference the less recombination frequency ,so we can derive from it a shorter map distance ) 3. __F___ In meiosis, there are two chromosome replications and one cell division.(one chromosome replication two cell divisions) VOCABULARY 1. _ zygotene _ The meiotic prophase stage in which the homologous chromosomes synapse(联会). 2. _anaphaseThe mitotic phase directly following metaphase（中期）. 3. _________6_______ The variance of a ???distribution with 3 degrees of freedom. 4. _____female___________ The sex of an XXY Drosophila（果蝇）（A ratio） 5. _______testcross_________ A mating of type AaBbCc x aabbcc 6. ______narrow heritability__________The additive genetic variance divided by the total phenotypic variance. 7. ________autosome______The chromosomes other than the sex chromosomes MULTIPLE CHOICE SHORT PROBLEMS 1. How many kinds of gametes can be produced by an individual of genotype!AABbccDdEeFfGgHH? A. 2 B. 8 C. 16 D. 32 E. 64 2. Given a mating of type Aa x aa, what is the probability that a family of 5 children includes at least one homozygote? A.15/16 B. 2/3 C. 7/8 D. 31/32 E. 1/2 (1-(0.5)^5)=31/32 3. The ‘P value’ associated with a test statistic like X2 is A. The Pr that the null hypothesis is false B. The Pr that the null hypothesis is true C. One minus the probability that the null hypothesis is more likely than the alternative D. The Pr of obtaining an X2 value at least as deviant as that observed if the hypothesis is false E. The Pr of obtaining a result at least as far from expected as observed if the hypothesis is true 4. Mrs. Smith has two brothers with hemophilia. What is the Pr that Mrs. Smith’s next child will be a hemophiliac if it is a boy? A. 1/2 B. 1/3 C. 1/4 D. 1/5 E. 1/6