human food safety of new animal drugs microbial …：新型动物药品的人类食品安全….pptxVIP

下载本文档

3
0
约9.37千字
约 41页
2019-09-07 发布于湖北
举报
版权申诉

human food safety of new animal drugs microbial …：新型动物药品的人类食品安全….pptx

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

1;FDA/CVM;Any compound present in the edible tissues after treatment with the new animal drug. Includes parent drug, metabolites, and any substance formed in or on food. The definition is broad enough to include resistant bacteria. ;Human Food Safety Assessment;Assess the Microbial Food Safety of New Animal Drugs in the following categories: Antimicrobial resistance development in drugs of human concern Potential disruption and/or development of antimicrobial resistance in the human intestinal bacteria ; Risk = Hazard x Exposure;Using a Qualitative risk assessment approach Assess antimicrobial drugs intended for food-producing animals regarding the development of antimicrobial resistance Address human exposure to antimicrobial resistant microbes through ingestion of animal-derived food ;;The hazard has been defined as human illness caused by an antimicrobial-resistant bacterium attributable to an animal-derived food commodity treated with a human antimicrobial drug of concern. In some instances, a hazard characterization is sufficient for a particular antimicrobial drug;Describes factors related to an antimicrobial drug and its use in animals that contribute to the emergence of antimicrobial resistant bacteria or antimicrobial resistance determinants in the animal;Mechanism of Activity Spectrum of Activity Pharmacokinetics Pharmacodynamics Antimicrobial Resistance Mechanism Antimicrobial Resistance Transfer Selection Pressure ;Hazard: Emergence of Antimicrobial Resistance Parameters: Mechanism of Activity – Class of Drug, targeted action Spectrum of Actvity – Gram +/- activity, susceptibility data Antimicrobial Resistance mechanisms – Structural, efflux, gene Antimicrobial Resistance Transfer – chromosomal, mobile element Selection Pressure – co-selection ;Describes likelihood of human exposure to food-borne bacteria of human health concern through animal-derived food products ;Probability that humans consuming animal derived foods will be exposed to resistant