妊娠免疫调节以和孕激素在辅助生殖医疗中应用新进展课件.ppt

The diagram shows a pre-implantation-stage blastocyst (approximately 6 -7 days after conception) and the tightly networked processes thought to be necessary for uterine receptivity and blastocyst apposition and adhesion. COX-2 = cyclooxygenase-2 EGF = epidermal growth factor LIF = leukemia inhibiting factor Progesterone (bended arrow) plays a crucial role not only in preparing the endometrial stroma for the successful blastocyst adhesion But also in pathways involving cytokines prostaglandin Source Norwitz et al., N Engl J Med, 2001 The fetal and the maternal tissues are in close harmony