RCT文献质量评价课件.pptVIP

RCT文献质量评价;严格文献评价 －－证据的质量;Meta-分析的基本步骤;Tools for assessing quality and risk of bias;Cochrane handbook5_0_1 第八章: Table 8.5.c: Criteria for judging risk of bias in the ‘Risk of bias’ assessment tool ;Assessment of risk of bias;;(1) Was the allocation sequence adequately generated?;（1）随机分配方案产生 ;(2)?Was allocation adequately concealed?;（2）分配方案隐藏 ;随机分配方案的隐藏;(3)?Was knowledge of the allocated intervention (s) adequately prevented during the study? （ Blinding?）;盲法 (Blindness);盲法的分类;不能把“分配隐藏”与盲法混淆 分配隐藏实质是产生随机序列者和决定分配序别者不能参与纳入受试者，也不宜参与以后的试验过程，尤其不能参与结果的测量。 ;盲法;(4)?Were incomplete outcome data adequately addressed?;结果数据不完整 ;(5) Are reports of the study free of any suggestion of selective outcome reporting?;选择性报告结果 ;(6) Was the study apparently free of other problems that could place it at risk of bias?;其它影响真实性因素：无其它偏倚;Summary assessments of the risk of bias for each study;总分评分细则;如各评价条目均为A级, 则为低度偏倚, 发生各种偏倚的可能性最小,所有评价指标均有详细描述; 质量评为A级; 若有一个条目或多个条目为B, 则该试验有发生相应偏倚的中等度可能性,所有评价指标中至少有1项指标提及但未详细描述; 质量评为B级; 如其中有一个条目或多个条目为C,则该试验有发生相应偏倚的高度可能性, 所有评价指标中至少1项指标为不充分或未使用; 质量评为C级;;;Entry;Blinding? (Mortality);Jadad score ;质量评价注意事项;非随机对照试验的质量评价;非随机对照试验的系统评价方法