总维生素D检测的重要性及临床意义课件.pptVIP

总维生素D检测的重要性及临床意义 维生素D营养状况的评判标准 聊城地区育龄女性VD状况 统计成人共 636人 VD10 263 41.35% 10≤VD20 313 49.21% 20≤VD30 37 5.82% VD≥30 23 3.62% 聊城地区儿童VD状况 儿童统计364人 VD10 11 3.02% 10≤VD20 65 17.86% 20≤VD30 130 35.71% VD≥30 158 43.41% * 维生素D的内分泌、旁分泌和自分泌功能 维生素D在钙平衡中的作用 维生素D可减低自身免疫性疾病发病率 Vitamin D supplementation is associated with a lower risk of autoimmune diseases. In a Finnish birth cohort study of 10,821 children, supplementation with vitamin D at 2000 IU/d reduced the risk of type 1 diabetes by approximately 78%, whereas children who were at risk for rickets had a 3-fold higher risk for type 1 diabetes. In a case-control study of 7 million US military personnel, high circulating levels of vitamin D were associated with a lower risk of multiple sclerosis. Similar associations have also been described for vitamin D levels and rheumatoid arthritis. 维持充足的维生素D水平可以减低多种自身免疫病的发病风险 A prospective cohort study of children born in Finland during the year 1966 and followed for thirty years found that those who received supplemental vitamin D during the first year of life had a significantly lower risk of developing IDDM A recent case-control study in U.S. military personnel, including 257 cases of diagnosed MS, found that white subjects in the highest quintile of serum 25-hydroxyvitamin D (99.1 nmol/L) had a 62% lower risk of developing MS . postmenopausal women with the highest total vitamin D intakes were at significantly lower risk of developing RA after 11 years of follow-up than those with the lowest intakes 多发性硬化症与纬度的关系 People living closer to the equator are at decreased risk of developing MS Similar trends: cancer, hypertension 促进细胞分化、抑制增殖---维生素D降低肿瘤发生率 The active form of vitamin D, 1,25-dihydroxyvitamin D, inhibits proliferation and stimulates the differentiation of cells . ? Holick MF. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr. 2004;79