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Protein Refolds to Perform Second Job
The transcription factor RfaH unfolds and then refolds into a new conformation to become a translation factor. Ian Chant reports
July 25, 2012
Secret identities aren’t just for superheroes anymore. Researchers have found that a protein present in everything from amoebas to people is living a double life. Once it binds to DNA, the protein, called RfaH, rips apart—and then refolds into a different shape, to do a different job.
RfaH is a transcription protein—attached to or freed from a stretch of DNA, it determines if a gene is expressed or not. But once the
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