研人类基因组学.pptVIP

Prerequiste of human genome sequencing: genetic and physical maps Genetic Mapping – based on recombination frequency (expressed as cM); Key word : co-segregation Physical Mapping – actual molecular distance in nucleotide base pairs (expressed as bp, kb, or mb) Key word: contig Genetic maps are important crutches for physical maps 2011-10-25 向光盛 长江大学医学院 Genetic Markers for Mapping Polymorphic markers for genetic mapping. RFLPs – restriction fragment length polymorphisms SSRs – simple sequence repeats (also called microsatellites) For High-resolution physical mapping S