肿瘤侵袭和转移.pptVIP

MMP mainly involved in metastasis are different in some tumors MMP induction by cell-cell interaction and emmprin Emmprin(extracellular matrix metalloproteinase inducer) The cDNA for human emmprin encodes a 269 amino acid residue A signal peptide of 21 aa A 185-aa extracellular domain consisting of two regions characteristic of the immunoglobulin (Ig) superfamily A 24-aa transmembrane domain A 39-aa cytoplasmic domain Induction and activation of MMP Emmprin is a surface molecule on tumor cells that stimulates nearly fibroblasts to produce collagenase, GelA and stromelysin-1 Emmprin also stimu