留学生心绞痛第23章.pptVIP

* Antiangina Pectoris Agents 28 §1 Brief Introduction Coronary heart disease Teatment of Angina Pectoris: 1. Dilation of blood vessels 2. Reducing blood lipid level 3. Reducing blood glucose level 4. Antithrombosis 5. Anti-pain Contractility Heart Rate Cardiac Wall Tension Preload and Afterload 1. Beta-Blockers 2. Glyceryl trinitrate 3. L-CB Anti-angina pectoris Agents Coronary heart disease prescription: Nitrate esters Antihypertensive agents Antilipemic agents §2 Nitrate Vasodilator In blood vessel wall, GTN produce NO with the help of mitochondrial aldehyde dehydrogenase (mtALDH)