神经内分泌学生长轴.pptVIP

Growth hormone(GH): Secrete by anterior pituitary Single peptide chain Composed of 191 aa molecular mass: 22kDa GH: Somatotrophin, Growth hormone is regulated by GHRH, SS (SRIH), and hypothalamic peptides as well as complex neuroendocrine network. 1). GHRH and SS regulation of GH release Growth hormone releasing hormone （GHRH） 44 peptide distribution in ARC , PVN , AMH, and VMH GH release GH DNA→mRNA GH cell in pituitary proliferate and differentiate GHRH via： GHRH to anterior pituitary → to bind its receptor (GHRH receptor) → activate G-protein → induce cAMP-P