Subcellular localization of HCV core protein regulates its ability for p53 activation and p21 suppression 丙型肝炎病毒核心蛋白的亚细胞定位调节其p53激活和p21抑制能力.pdf
- 1、本文档共7页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
查看更多
BBRC
Biochemical and Biophysical Research Communications 294 (2 2) 528–534
Subcellular localization of HCV core protein regulates its ability
for p53 activation and p21 suppression
Takayuki Yamanaka,a Tatsuhiko Kodama,b and Takefumi Doia,*
a Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan
b Research Center for Advanced Science and Technology, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan
Received 15 April 2 2
Abstract
Hepatitis C Virus (HCV) is a single stranded RNA virus causing non-A and non-B hepatitis. Core protein is a viral capsid protein
that plays an important role in the pathogenesis of HCV. The companion report revealed that an innate form (amino acids [a.a.]
1–191) regulated subcellular localization of a mature form (a.a. 1–173). It was also shown that the innate form in the cytoplasm
enhanced the p21 expression and the mature form in the nucleus suppressed the p21 expression. Here we report that the core protein
in the cytoplasm increases the amount of p21 via activating p53, and the core protein in the nucleus decreases the amount of p21 by
the p53-independent pathway. These observations suggest that the regulation of p21 expression by the core protein via subcellular
localization might decide the fate of infected cells either to the proliferation or to the apoptosis. 2 2 Elsevier Science (USA). All
rights reserved.
Keywords: Hepatitis C virus (HCV); Core protein; Processing; Subcellular localization; Heteromultimer
您可能关注的文档
- The changes of miRNA expression in rat hippocampus following chronic lead exposure 慢性铅暴露对大鼠海马mirna表达的影响.pdf
- Staruml使用方法(不仅仅是软件教程).pdf
- SQL笔试题带答案.pdf
- SARAH KANE 4.48 PSYCHOSIS 莎拉凯恩 精神病.pdf
- THE CO-AREA FORMULA 面积计算公式.pdf
- The Codes of Gender - Media Education Foundation 性别传媒教育基金会守则.pdf
- STC90c516RD-使用详解简介.pdf
- RNA-seq学习名词解释.pdf
- telc_deutsch_b1_zd_uebungstest_1 德国电视应用测试.pdf
- PSInSAR和SqueeSAR卫星雷达分布散射体地面变形监测技术.pdf
文档评论(0)