环蕃化学-公开课件（精选）.pptVIP

At high concentration polymerization reactions dominate. The probability of a molecule meeting a second molecule decreases as the concentration decreases; therefore, the more dilute the solution, the better the ratio of macrocycle to polymer. The high dilution method is used in the synthesis of macrocyclic compounds. Typical high dilution reactions involve milligrams or tens of milligrams of reactants in solvent volumes of the order of litres. In a typical high dilution synthesis, solutions of each component are slowly added dropwise to a large volume of solvent, keeping the concentration of