补肺肾清热饮治疗气道高反应性咳嗽临床研究.PDFVIP

2010;30(9) 南方医科大学学报(JSouthMedUniv) 窑2179 窑 补肺肾清热饮治疗气道高反应性咳嗽的临床研究 张 印袁杨明会袁窦永起袁刘毅渊解放军总医院中医研究所袁北京100853冤 摘要院目的通过观察气道高反应性咳嗽患者临床症状以及上呼吸道红外线图像的变化袁评价中药治疗气道高反应性咳 嗽的疗效遥 方法 以明确诊断为气道高反应性渊气道激发试验阳性冤的咳嗽患者60例为纳入对象袁随机分为西药对照 组和中药治疗组袁各30例遥 中药治疗组给予补肺肾清热饮袁西药对照组给予茶碱缓释胶囊治疗遥分别在治疗前尧治疗 1 个月后观察患者咳嗽尧咯痰尧咽痛等症状变化袁并对患者进行上呼吸道红外线检查袁观察补肺肾清热饮治疗气道高反应 性咳嗽的疗效遥 结 治疗 1个月后中药组患者咳嗽尧咯痰尧咽痛尧喉痒等症状轻于西药对照组渊P0.05冤曰上呼吸道红外 线热态图检查病变组织与周围正常组织温差变化幅度袁中药治疗组显著大于西药对照组渊P0.01冤遥 结论补肺肾清热 饮治疗气道高反应性咳嗽袁可以减轻患者症状袁改善患者上呼吸道图像的异常状态遥 关键词院咳嗽曰气道高反应性曰补肺肾清热饮曰中医药疗法 中图分类号院R256.11 文献标识码院A 文章编号院1673-4254渊2010冤09-2179-02 EffectofBufeishenqingredecoctiononbronchialhyperresponsiveness-inducedcough ZHANGYin,YANGMing-hui,DOUYong-qi,LIUYi TraditionalChineseMedicineInstituteofGeneralHospitalofPLA,Beijing100853,China Abstract: Objective To evaluate the effect of traditional Chinese medicine preparations on bronchial hyperesponsiness (BHR)-inducedcough. MethodSixtypatientswithcoughduetoBHR (shownbypositivebronchialprovocationtest) were randomlydividedintoChinesemedicinegroup(n=30)andcontrolgroup(n=30)toreceiveBufeishenqingredecoctiontwicea dayand100mgtheophyllinesustained-releasecapsulestwiceadayforonemonth, respectively. Thechangesoftheclinical symptomswereobservedduringthetreatmentandbronchialinfraredimagingwasperformedbeforeandafterthetreatment. Results ThesymptomsofpatientsintheChinesemedicinegroupweremoreeffectivelyalleviatedthanthoseofthecontrol group(P0.05).Thedifferenceinthetemperaturebetweenthebronchiallesionsandthesurroundingnormalmucosachanged moreobviouslyintheChinesemedicinegroup(P0.01). ConclusionBufeishenqingredecoctioncanrelievethesymptomsand improvetheabnormalitiesininfraredimagingofpatientswithBHR-inducedcough. Keywords:cough;bronchialhyperesponsiness;Bufeishenqingredecoction;traditionalChinesemedicine 气道高反应性渊BHR冤是指气道对正常不引起或 1 对象和方法 仅引起轻度应答反应的刺激物出现过度的气道收缩