颌面骨工程学文献汇报.pptxVIP

Development of a biointegrated mandibular reconstruction device consisting of bone compatible titanium fiber mesh scaffold;实验步骤;A cuboid with 10 mm square and 5 mm thick ;For the animal study, a segmental bone defect 10 mm in length was created in rabbit mandibular bone ，followed by its reconstruction using a Ti fiber mesh scaffold ;The scheme of the three-point bending test to the Ti fiber mesh scaffold Although the scaffold was gradually deformed by the vertical force, it remained unbroken by approximately 500 N; (A) A mandible reconstructed using a thin hydroxyapatite (HA)-coated Ti fiber mesh scaffold. (B) An axial computed tomography image of the same sample. Bone length on the surface of the scaffold (double arrowheads) was calculated. (C, D) The average bone length outside the scaffold was 9 mm in HA-coated scaffolds, suggesting that most of the 10-mm bone defect had been restored ;Bone formation was evident in HA-coated scaffolds, which had integrated with the newly formed bone tissue (arrows). The lower row of 3D images, Ti has been excluded as much as possible, but the site surrounding the screw hole seemingly exhibited a bone-like tissue. We included this bone-like tissue in our comparison because it was difficult to exclude this area. Statistical analysis revealed significant differences between the groups. The volume of new bone in HA-coated scaffolds was significant and almost four-fold higher than that in non-coated scaffolds. However, this bone formation accounted for less than 50% of the total pore space even in HA-coated scaffolds, suggesting that less bone formation occurred with in the scaffold than expected. *P 0.05.;(B) The graph (lower left) shows the resistant curve of both groups to the bending force. The dotted lines showthe gradient of a tangent to the resistant curve. In hydroxyapatite (HA)-coated scaffolds, the gradient of a tangent to the resistant curve was steeper than that in non-coatedscaffolds. (C) The mean