Biological activities and safety of Thanaka (Hesperethusa crenulata) stem bark马齿苋茎皮的生物活性及安全性.pdfVIP

Contents lists available at ScienceDirect Journal of Ethnopharmacology j o u rn al h omepage: w w w. elsev /locate/jethpharm Biological activities and safety of Thanaka (Hesperethusa crenulata) stem bark Sakulna Wangthong a , Tanapat Palaga b , Sirirat Rengpipat b , Supason P. Wanichwecharungruang c,∗ , Panpilai Chanchaisak a , Michael Heinrich d a Program in Biotechnology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand b Department of Microbiology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand c Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand d Center for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, London WC1N 1AX, United Kingdom a r t i c l e i n f o a b s t r a c t Article history: Ethnopharmacological relevance: The stem bark powder of Hesperethusa crenulata or Thanaka has been Received 17 March 2010 used on the face by Myanmar women for more than a thousand years as a skin care regiment. Received in revised form 20 August 2010 Aim of the study: The aim of the current study was to both verify the safety and evaluate some biological Accepted 22 August 2010 activities of the Thanaka bark. Available online xxx Materials and methods: Maceration of the Thanaka bark powder resulted in hexane, dichloromethane, ethyl acetate, methanol, 85% ethanol and water extracts. For the safety evaluation, cytotoxicity and Keywords: genotoxicity of