基因分型在乳腺癌个体化治疗中的应用陈振东.pptVIP

Management of BRCA1 or BRCA2 Carriers intensive screening, chemoprevention, prophylactic surgery. Who Should Be Referred For Counseling and Tested For BRCA1 and BRCA2 Mutations? Breast cancer≤40 yr old At least two instances of breast cancer ≤ 50 yr old Ovarian cancer and breast cancer in the same lineage (breast ≤ 50 or ≥2 cases of breast cancer) Male breast cancer (if close relative has breast or ovarian cancer) More than three cases with breast cancer in the same lineage Relatives of known BRCA1 or BRCA2 carrier 基因检测的潜在影响 阳性(基因突变)检测结果 正面影响 排除了疑问和怀疑 较早检出癌前病变和预防癌症 可计划生育并为将来治疗做好思想和财力准备