蜕膜细胞早熟衰老与早产研究进展.PDF

网络出版时间：2015-07-03 15:58 网络出版地址：/kcms/detail/31.2035.Q1558.005.html 中国细胞生物学学报 Chinese Journal of Cell Biology 2015, 37(7): DOI: 10.11844/cj cb.2015.07.0051 蜕膜细胞早熟衰老与早产研究进展 * * 马珍子 李世杰 严云勤 马兴红 (东北农业大学生命科学学院, 哈尔滨150030) 摘要 世界范围内, 5%~ 18%的妊娠与早产相关, 早产是导致新生儿死亡的最主要原因。每 年大约有1 500万早产儿降生, 由早产导致的新生儿死亡每年超过100万。尽管已发现许多因素与 早产有关, 但对早产的发病机制仍认识不深, 临床上仍然缺乏有效的预防与治疗手段。细胞衰老在 各种生物学过程中发挥重要作用。最近的研究表明, 子宫蜕膜衰老可能决定分娩的时机, 蜕膜早熟 衰老是早产的重要诱因。该文总结了最近关于细胞衰老的最新观点, 综述了蜕膜细胞早熟衰老与 早产关系的最新研究进展。 关键词 蜕膜化; 细胞衰老; 早产 Research Progress of Premature Decidual Senescence and Preterm Birth Ma Zhenzi, Li Shijie, Yan Yunqin*, Ma Xinghong* (College of Life Science, Northeast Agricultural University, Harbin 150030, China) Abstract Preterm birth accounts for 5% to 18% of pregnancies worldwide and is a leading cause of infant morbidity and mortality. Each year, about 15 million preterm neonates are born and over 1 million neonatal deaths happen. Although several risk factors were found to contribute to this disorder, the mechanisms underling preterm birth are still not well understood and the effective prevention and treatment are not quite available. Cellular senescence is implicated in several biological processes. Recent studies suggest that decidual senescence may determine the timing of birth, and the premature decidual senescence may be the common cause of preterm birth. In this paper, we summarize the c