静息心率与慢性心力衰竭患者炎症因子及BNP的关系.docVIP

静息心率与慢性心力衰竭患者炎症因子及BNP 的关系 陆铭 蒋庆渊 刘春兰 刘莹莹 凌佳 阚丽红 庄晓华 蔡振荣* 上海市浦东医院心血管内科，复旦大学附属浦东医院心血管内科，上海 201399； 摘要目的：探讨慢性心力衰竭患者入院时静息心率与炎症因子及血脑钠肽(BNP)关系。方法：选择2015.1～2016.6在上海市浦东医院心血管内科住院的180例纽约心脏学会（NYHA）心功能分级Ⅱ~Ⅳ级的CHF患者，按静息心率将患者分为A组(心率≤70次/min)，B组(心率: 70~90次/min)，C组(心率＞90次/min)；患者入院时检测炎症因子C-反应蛋白（CRP）、白介素-1β（IL-1β）、白介素-6（IL-6）、肿瘤坏死因子（TNF-α），血清BNP 水平以及左室射血分数（LVEF），比较各组相关指标的差异。结果：三组在炎症因子CRP、IL-1β、IL-6、TNF-α，血清BNP 水平及LVEF存在显著差别(P＜0.01)，与A组及B组比较，C组患者LVEF 偏低，炎症因子CRP、IL-1β、IL-6、TNF-α及BNP 水平明显增高(P＜0.01)；与A组相比，B组患者LVEF 偏低(P＜0.01)，炎症因子CRP、IL-1β、IL-6、TNF-α及BNP 水平明显增高(P＜0.01)；Pearson相关分析显示静息心率与炎症因子CRP、IL-1β、IL-6、TNF-α及BNP 呈正相关（P＜0.05）；与LVEF呈负相关。结论：静息心率水平与慢性心力衰竭患者炎症因子及BNP 水平密切相关。 [关键词]：静息心率；炎症因子；慢性心力衰竭；脑钠肽 The association between resting heart rate,inflammatory factor and BNP concentration in patients with chronic heart failure LU Ming JING Qingyuan LIU Chunlan LIU Yingying LING Jia KAN Lihong ZHUANG Xiaohua CAI Zhenrong* Department of Cardiology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China [ABSTRACT] Objective：To evaluate the relationships between resting heart rate,inflammatory factor and BNP concentration in chronic heart failure patients. Methods：From January 2015 to June 2016, A total of 180 CHF patients were enrolled and stratified to group A(≤70b.p.m) , groupB(70~90b.p.m) and groupC(90b.p.m) according to resting heart rate, The concentration of C-reaction protein (CRP), interleukin-1β(IL-1β), interleukin-6 (IL-6),tumor necrosis factor α(TNF-α),brain natriuretic peptide(BNP)，left ventricular ejection fracetion(LVEF)? were measured on admission. Results：LVEF of the patients in the groupC decreased significantly compared with that of groupA and groupB (P0.01),Inflammatory factors(CRP, IL-1β, IL-6,TNF-α) and BNP levels of CHF patients in groupC were significantly higher than those in groupA and groupB (P＜0.01). LVEF of the patients in the groupB decreased significantly compared with that of groupA (P0.01), Inflammatory factors(CRP, IL-1β, IL-6