微RNA通过调节上皮间质转化影响肿瘤转移.pdf

Hereditas (Beijing) 2014 年7 月, 36(7): 637 ―645 综 述 微RNA 通过调节上皮间质转化影响肿瘤转移 1,2 1 1,2 1,2 1,2 1,2 杨丽华 , 沈星凯 , 李静秋 , 杨杰 , 乐燕萍 , 龚朝辉 1. 宁波大学医学院生物化学与分子生物学研究所, 宁波 315211; 2. 浙江省病理生理学技术研究重点实验室, 宁波 315211 摘要:肿瘤细胞向远处转移受多因素调控, 涉及多个基因, 需要经历一系列连续的、可选择的级联事件。上皮 间质转化(Epithelial-mesenchymal transition, EMT)是肿瘤细胞转移中的关键步骤, 但肿瘤发生 EMT 的机制至今 尚不完全明确。微RNA (MicroRNA, miRNA)是一类内源性、非编码小分子RNA, 可在转录后水平负调控EMT 相关基因的表达, 在肿瘤转移中发挥重要作用。文章主要就EMT 与肿瘤转移的关系、影响EMT 的转录因子, 以 及miRNA 通过靶向EMT 相关的转录因子影响肿瘤转移等方面进行了综述。 关键词:微RNA; 肿瘤转移; 上皮间质转化 MicroRNAs affect tumor metastasis through regulating epithelial- mesenchymal transition 1,2 1 1,2 1,2 1,2 1,2 Lihua Yang , Xingkai Shen , Jingqiu Li , Jie Yang , Yanping Le , Zhaohui Gong 1. Institute of Biochemistry and Molecular Biology, Ningbo University School of Medicine, Ningbo 315211, China ; 2. Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 315211, China Abstract: Distant metastasis of tumor cell is a series of continuous, selectable cascades of events regulated by multiple factors and genes. Epithelial-mesenchymal transition (EMT) is a critical step during cancer metastasis. However, the mech- anism of EMT in tumor is not yet fully elucidated. MicroRNAs (miRNAs) are a class of non-coding small endogenous RNAs that negatively regulate EMT-related genes at the post-transcriptional level and play critical roles in cancer metastasis. This review mainly focuses on the topics that include the relationship of EMT and t