《缺血再灌注损伤Ischemia-Reperfusioninjury》-公开课件（设计）.pptVIP

Ischemia-Reperfusion injury Ischemia Anesthesiologist: MI, peripheral vascular insufficiency, stroke, and hypovolemic shock Restoration of blood flow to an ischemic organ is essential to prevent irreversible cellular injury Reperfusion may augment tissue injury Ischemia-Reperfusion Thrombolytic therapy, organ transplantation, coronary angioplasty, aortic cross-clamping, or cardiopulmonary bypass Severe: systemic inflammatory response syndrome (SISS) or multiple organ dysfunction syndrome (MODS) Account for 30–40% of the mortality in tertiary referral ICU Cellular change during Ischemia Altere