恶性肿瘤代谢特点及其与炎性介质的相关性研究进展.pdf

476 2019 46 5  Cancer Res Prev Treat,2019,Vol.46,No.5 · · 肿瘤防治研究 年第 卷第 期 doi:10.3971/j.issn.1000-8578.2019.18.1490 ·综  述· 恶性肿瘤代谢特点及其与炎性介质的相关性 研究进展 1 2 3 2 唐翠娟 ，荣震，莫春梅，郑韦平 Advances in Metabolic Characteristics of Malignant Tumors and Their Correlation with Inflammatory Mediators TANG Cuijuan1 2 3 2 , RONG Zhen , MO Chunmei , ZHENG Weiping 1. Graduate School of Guangxi University of Traditional Chinese Medicine, Nanning 530000, China; 2. Department of Oncology, The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nanning 530000, China; 3. Department of Hepatology, The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nanning 530000, China Corresponding Author: RONG Zhen, E-mail: rongzhenw@163.com Abstract: Malignant tumor is are a kind of high-energy metabolic disease. Due to the role of malignant tumors themselves, the human body’s stress response to malignant tumors and the measures in the anti-cancer treatment process lead to the special characteristics of cancer patients, such as lipolysis and increased fatty acids oxidation, decreased lean tissue group, insulin resistance, and protein metabolism disorders etc. A large number of metabolites, such as lipopolysaccharide (LPS), lactic acid, arachidonic acid metabolite (PGE2), free fatty acid (FFA), etc., often induce chronic low-grade inflammation.  Many tumors occur in the areas  of infection, chronic irritation and inflammation, so the influence of the inflammatory microenvironment on  tumors has become the focus in the field of scientific research. In the process of tumor body metabolism, many inflammatory mediators are involved, so this paper summarizes the relationship between tumor energy  metabolism ch