欧哈勒OHara连续式包衣机性能及优势.pdfVIP

1 April 2011 Tablets Capsules tablet coating Advantages of continuous James Marjeram O’Hara Technologies pharmaceutical tablet coating Many tablet manuf acturers have become interested in continuous • Faster, easier, and less expensive scale up from RD tablet coating to replace or supplement traditional batch-sty le to pilot scale operation and from pilot scale opera tablet coating . This article discusses the reasons f or their interest tion to production. All scale up can be done in simi lar machines or drum sizes; and weig hs the advantag es and disadvantag es. It also discusses • Ability to vary batch sizes according to product the importance of tablet movement throug h continuous coaters. requirements and demand. It’s possible to coat 150 to 30,000 kilogram batches in a single machine; or many decades, pharmaceutical manufacturers have • Increased equipment utilization and thus less down relied on batch operations, so why would they now con time because the equipment spends more time coat sider continuous tablet coating or other continuous oper ing and less time in unproductive process steps; and F ations? There are several reasons: • Contained processes—from start to finish—are benefi • Potential to employ on line or at line process analyt