国家基金申请存在的问题和对策教学讲义.pptVIP

国家基金申请存在的问题和对策;申请书需回答的问题;标 题; 神经元凋亡时SP1对BH3-only蛋白Bim的转录调控;神经元凋亡时SP1对BH3-only蛋白Bim的转录调控;CaMKII磷酸化GSK-3对去极化介导的神经元存活的调控;立项依据;Fig.6 Mithramycin A, a SP1-DNA binding inhibitor, attenuates bim upreguation by activity deprivation in CGNs. (A) Mithramycin A attenuates the upregulation of BimEL induced by activity deprivation in a dose dependent manner. CGNs were placed in 25K or 5K media in the absence or presence of mithramycin A at the indicated concentrations for 6 h. BimEL expression was assessed by Western blot as described in Fig.1(A). Results shown are representative of four separate experim