病毒学双语版课件赏识.pptVIP

Like T-cell anergy, apoptosis could potentially be induced in large numbers of uninfected cells by factors released from a much smaller number of HIV-infected cells. In addition to clonal deletion as a normal part of the evolution of the T-cell repertoire, apoptosis may be induced following T-cell activation as a negative regulatory mechanism to control the strength duration of the immune response. HIV infection of T-cells induces an activated phenotype, e.g. surface expression of CD45 HLA-DR markers, which suggests that these cells may be inevitably doomed due to activation of the apoptosis