儿童紫癜性肾炎.pptxVIP

儿童紫癜性肾炎;紫癜性肾炎 (Henoch-Schonlein purpura nephritis，HSPN) ;诊断标准（2008，紫癜性肾炎诊治循证指南 ）;;儿童紫癜性肾炎;病因;发病机制;乙酰半乳糖胺;CD71与IgA1; Upper respiratory tract infection Gastrointestinal infection ↑Production of Anti-glycan IgG or IgA1 Polymeric Gd- antibodies bind to Gd Formation of IgA1-IgG and IgA1- IgA1 immune Glomerular Activation of mesangial cells Initiation of glomerular inflammation (cellular proliferation, matrix expansion) ;儿童紫癜性肾炎;病理检查的目的;肾活检指征;病理分级;HSPN的ISKDC病理分级;我国儿童HSPN的肾脏病理以Ⅱ级和Ⅲ级为主，极少V级和Ⅵ级;HSPN预后不良的独立危险因素 ;肾小管间质病理分