《检验科 外周血涂片检查》.ppt

血小板形态异常 小血小板、大血小板、巨大血小板和蛇形血小板。 Bernard-Soulier syndrome,BSS 伯-苏综合征，巨血小板综合征 血小板膜GPⅠb/Ⅸ或GPⅤ异常 Agranular Platelets Gray platelet syndrome ( α-granule deficiency) The platelets are characteristically larger than normal and are pale gray forms. 血小板散在分布、血小板成簇聚集 血小板无力症-thrombasthenia 亦称Glanzmann病 血小板膜GPⅡb/Ⅲa异常 May-Hegglin disease Gray blue giant neutrophil inclusion (arrow) and giant platelets, the size of a red cell. platelet abnormalities Post splenectomy in a patient with PMF. Note two micromegakaryocytes . Thrombocythemia with a wide range of platelet size ranging to giant platelets with abnormal internal structures. Pseudothrombocytopenia produced by aggregation of platelets around the neutrophils. Platelet satellitosis (platelets encircling a neutrophil) occurs when a patient has a serum factor that reacts to the anticoagulant EDTA. 内皮细胞 成纤维细胞（纤维母细胞）、内皮细胞、巨噬细胞和脂肪细胞 脂肪细胞、组织嗜碱细胞（肥大细胞）、组织嗜酸细胞、吞噬细胞和成骨细胞。 各种形态破骨细胞 退化细胞，涂抹细胞，蓝状细胞 细胞退化后形成，多见于淋巴细胞白血病 Cryoglobulin deposits on a blood smear 三、常见血液疾病外周血细胞形态改变 The RBCs here are smaller than normal and have an increased zone of central pallor. This is indicative of a hypochromic microcytic anemia. There is also increased anisocytosis and poikilocytosis . The most common cause is iron deficiency. Persons most at risk are children and women in reproductive years (from menstrual blood loss and from pregnancy). Tuck细胞（塔克细胞），有时称过渡淋巴细胞。 （五）、浆细胞系统 原始浆细胞、幼稚浆细胞、成熟浆细胞 Plasmablast Binucleated plasma cell Flamed plasma cell Russell Body Mott Cell Dutcher bodies Dutcher Body and Mott Cell Comparison (六）、巨核细胞系统 原始巨核细胞、幼稚巨核细胞、 颗粒型巨核细胞、产血小板巨核细胞。 血小板形态 大小的变化 形态的变化 血小板分布情况 （三）、单核细胞系统 各种单核细胞 原始单核细胞、幼稚单核细胞、成熟单核细胞 Monocyte, vacuoles. occur if the cells are exposed to Na2EDTA anticoagulant or as a result of inflammatory states. 吞噬色素颗粒的单核细胞和具有空泡的单核细胞 大单核细胞 吞噬血小板的单核细胞 吞噬血小板和红细胞的巨噬细胞 四、淋巴细胞系统 原始淋巴细胞、幼稚淋巴细胞、成熟淋巴细胞 三种白血病细胞形态比较 Variant or atypical lymphocytes 异型淋巴细胞 为一种形态变异的淋巴细胞，多属T淋巴细胞，其形态的变异是在病毒或过敏原等因素刺激下增生亢进甚至发生母细胞化的结果。正常人