术中预缺血对猪骨骼肌保护作用的实验研究.docVIP

???? 术中预缺血对猪骨骼肌保护作用的实验研究 ???? ????【摘要】　目的　研究术中预缺血对骨骼肌缺血坏死的保护作用及相关的肌肉代谢变化。方?法　10只猪背阔肌瓣在4h缺血前先进行3个循环10min的术中预缺血，4 8h后用染色法记录肌肉成活率，于肌肉缺血前、缺血后2，4h和再灌流1.5h分别作肌肉活检。结果　4h缺血后的肌瓣，术中预缺血组成活率高出对照组44%，肌肉活检三磷酸腺苷(ATP)增加和乳酸降低(P0.05)。结?论　术中预缺血可增加骨骼肌对缺血坏死的保护作用，这与肌肉中能量代谢的减低相关。　　【关键词】　骨骼肌　术中预缺血　缺血坏死 Acute ischemic preconditioning protects against skeletal musc le infarction in the pig HE Wei, ZHANG Jianrong, ZHONG Anguo, et al.Plastic Surgery Hospital of Chinese Academy of Medical Sciences, Beijing 100041 　　【Abstract】　Objective　The aim of this study was to investigat e metabolism of ischemic muscle and the ef