DBS治疗的关键和病人管理.pptVIP

In PD, within 4–6 years of levodopa therapy, over one third of patients develop motor fluctuations and one third of patients develop dyskinesia. After 10 years of levodopa therapy, up to 80% of patients, and almost 100% of those with young-onset PD, develop motor complications In ET, up to 30% of patients will not respond to treatment with propranolol, and as many as 20% of patients cannot tolerate primidone. Ahlskog JE, Muenter MD. Frequency of levodopa-related dyskinesias and motor fluctuations as estimated from the cumulative literature. Mov Disord 2001; 16(3): 448–458. Hubble JP, Busenbar