肠道菌群和肥胖1.pptxVIP

肠道菌群和肥胖;肠道菌群和肥胖;肥胖的定义;肠道菌群和肥胖是一个新的热门话题;肥胖和正常人;史氏甲烷短杆菌和肥胖;产甲烷肥胖的人有较高的身体质量指数;肠道菌群致肥胖原因;肠道菌群致肥胖原理;肠道菌群致肥胖原理;;双胞胎胖瘦菌群比较;不同胖瘦人群肠道菌群数量;不同胖瘦人群肠道菌群种类;;The gut microbiota composition has been associated with several hallmarks of metabolic syndrome (e.g., obesity, type 2 diabetes, cardiovascular diseases, and non-alcoholic steatohepatitis). Growing evidence suggests that gut microbes contribute to the onset of the low-grade inflammation characterising these metabolic disorders via mechanisms associated with gut barrier dysfunctions. Recently, enteroendocrine cells and the endocannabinoid system have been shown to control gut permeability and metabolic endotoxaemia. Moreover, targeted nutritional interventions using nondigestible carbohydrates with prebiotic properties have shown promising results in pre-clinical studies in this context, although human intervention studieswarrant further investigations. These data underline the advantage of investigating and changing the gut microbiota as a therapeutic target in the context of obesity and type 2 diabetes.;肠道菌群致代谢紊乱机理;肠道菌群致肥胖-糖尿病机理;无菌鼠定植后代谢路径;;;菌群和肥胖;胖人肠道菌群多样化少;菌群和肥胖;肠道菌群和肥胖;Fiaf;;影响代谢的因素;肠道菌群影响代谢;;肠道微生态肥胖管理;一项引起世界关注的研究;NCD: 正常饮食， HFD: 高脂饮食， LB: 溶菌肉汤 ;Na Fei and Liping Zhao, An opportunistic pathogen isolated from the gut of an obese human causes obesity in germfree mice, The ISME Journal (2013) 7, 880–884.;;;;;;;;;;;;;;Jia, W et al., (2008) Gut microbiota: a potential new territory for drug targeting, Nature Reviews Drug Discovery. 7: 123-131.;聚焦肠道菌群治疗肥胖;Jia, W et al., (2008) Gut microbiota: a potential new territory for drug targeting, Nature Reviews Drug Discovery. 7: 123-131.;谢谢;