癌基因与癌20xx培训资料.ppt

? Retinoblastoma (RB) arises when both copies of the RB gene are deleted or inactivated. ? The RB product is a nuclear phosphoprotein whose state of phosphorylation controls entry into S phase. Nonphosphorylated RB sequesters 隔离 the transcription factor E2F . The RB-E2F complex represses certain target genes. E2F is released when RB is phosphorylated by cyclin/cdk complexes; E2F can then activate genes whose products are needed for S phase. Loss of RB prevents repression by RB-E2F , and means that E2F is constitutively available. The cell cannot be restrained from proceeding