补充多种微量营养素对学龄儿童营养状况的影响.docVIP

补充多种微量营养素对学龄儿童营养状况的影响 王 茵朱染枫陈永壮1来伟旗 陈建国荫士安2 浙江省医学科学院保健食品所杭州3100131 杭州市卫生监督所杭州310004 2 中国疾病预防控制中心营养与食品安全所北京100050 摘 要目的 为研究复合微量营养素补充剂对儿童营养状况的影响方法 将220名8~12岁 小学生随机分为2组一组补充多种微量营养素另一组服安慰剂实验采用双盲设计补充期为6个 月停止补充后1年再随访观察试验前后和停止补充1年后分别测量儿童的身高体重生化等指标 结果 补充组儿童的4h 负荷尿中维生素B 2维生素C 的排出量晨尿羟脯氨酸含量及羟脯氨酸与肌酐 比值都显著高于对照组; 补充组儿童的血清125-二羟基维生素D 3[125(OH2D 3]水平尺骨中点处的骨矿物质含量和骨密度也显著高于对照组补充组儿童的阅读速度学习能力及数学考试成绩均显著 优于对照组停止补充1年后随访观察结果显示干预组的血红蛋白含量仍显著高于对照组血清视黄醇含量趋势高于对照组补充组临界维生素A 缺乏发生率显著低于对照组结论 复合微量营养素补 充剂对改善儿童营养状况和学习能力有明显促进作用长期补充停止后某些有益效果仍将持续存在一 段时间[营养学报2006283198202]202] 关键词微量营养素随访效果干预儿童 中图分类号R 153.2 文献标识码A 文章编号 0512-7955 2006 03-0198-05 STUDY ON THE EFFECT OF MICRONUTRIENTS SUPPLEMENTATION ON NUTRITION AL STATUS OF CHILDREN WANG Yin, ZHU Ran-feng, CHEN Yong-zhuang 1, LAI Wei-qi , CHEN Jian-guo, YIN Shi-an 2 (Institute of Health Food , Zhejiang Academy of Medical Sciences, Hangzhou 310013;1 Hangzhou Agency for Public Health Inspection, Hangzhou 310004, Zhejiang ;2 Institute of Nutrition and Food Safety, Chinese Center for Disease Prevention and Control, Beijing 100050 Abstract Objective To study the effect of multi-micronutrients supplementation on nutritional status of children. Method 220 students aged 812 years were observed for 6 months and 1 year follow-up. A half of them was given the supplements, another half as placebo. Results In comparison with the placebo, the supplemented children had a higher urine excretion of vitamin B 2 and vitamin C after loading; a higher concentration of serum 1.25(OH2D 3, hydroxyproline and hydroxyproline/creatinine ratio in fasting urine, and a higher bone mineral content and bone mass density in mid-ulna. The supplemented children performed significantly better than the placebo in reading speed, learning capacity and arithmetic examinations. After one year there was still significant difference between intervention and control group in hemoglobin content and marginal vitamin A deficiency. Conclusion The micronutrients supplementation pl