嗜神经病毒躲避宿主先天性免疫反应机制及应用赵凌老师.pptVIP

嗜神经病毒躲避宿主先天性 免疫反应的机制及对策 赵凌教授 华中农业大学 10-15-2013 華十震崇太学 勤讀力 Rabies virus I8onm x 7bnm x Protein Cross Sectional Envelope Ribonucleoprotein bil ye posed of RI、 A nca tein Tha cro ed encased genomic R. Rabies Genome 華十震崇太学 match 50 nL H, P M G 勤讀力 Rabies pathogenesis fected brain via nerves other tissues such as eye, kidneys, salivary glands dorsal root gangho card to braina/ and travels up 3. Virus infects ne system 1. Virus enters Moves by retrograde via animal bite 2. virus replicates in muscle at site of bite Robert Hurt-USC Patients die of circulatory insufficie cardiac arrest and respiratory fat 華十震崇太学 勤讀力 Rabies infection and innate immunity Gene category and identification Intered im I2C SHERY R2 Toll-like reccptors genes IFN-uS NNE丶 -x-C)MIG 華十震崇太学 Wang et al. Journal ot virology, 2005 4 重组狂犬病病毒构建 BsiWI Nhel HEHP1a□ HEP-RANTESH lEP-P10 華十震崇太学 Zhao ef al. Journal of Virology, 2009 5