医学驱动突变与恶性肿瘤诊断与治疗.pptVIP

驱动突变与恶性肿瘤的诊断与治疗 南京大学医学院附属鼓楼医院 王立峰 Characteristics of cancer cells ●c| onal origin Immortality and telomeres o Genetic instability Loss of contact inhibition and anchorage-dependent growth Progressive independence of proliferation from growth factors and nutrients Metastasis Cause of overproduction of cancer cells Failure of abnormal cells to undergo apoptosis Genetic abnormalities that inappropriately stimulate cell proliferation Abnormalities of tumor-suppressor genes e Tumor angiogenesis The essence of malignant tumor 肿瘤的发生是环境因素和遗传因素共同作用的 结果 ●环境因素只有改变遗传物质的结构和功能才能 使正常细胞转变为癌细胞 ●肿瘤发生的本质是体细胞