人类疱疹病毒(1)精美生物医学教程教案.ppt

人 类 疱 疹 病 毒;;Main properties;;; 病毒; Herpes simplex virus (HSV);  Herpes simplex virus （ HSV ）; Pathogenicity;;;HSV2 Genital herpes: common seen Skin herps : as HSV1 Neonatal herpes : during birth, is a severe disease skin, eye, month lesion encephalitis multiple organ disseminated (多器官感染) Latent infection：sacral ganglia (骶神经节);;;Latent and recurrence infection HSV1,HSV2 neuron virus reactivate , replication axon (神经纤维) peripheral sites, skin or mucous membrane HSV1：口唇部疱疹 HSV2：genital herpes ;; Varicella-zoster virus （VZV） 水 痘 带 状 疱 疹 病 毒;;;Zoster (带状疱疹) Seen in adults Severe pain and vesicle, often in chest ;;; Cytomegalovirus (CMV) 巨 细 胞 病 毒;; Pathogenicity; Diseases;; Epstein-Barr virus EBV; Pathogenecity ;Diseases Infectious mononucleosis Transmitted by infected saliva More seen in adolescents and young adults Fever, sore throat, WBC incraesed Distinguish with leukemia heterophil agglutination (异嗜凝集试验)：heterophil Ab can agglutinate sheep RBC Burkitt’s lymphoma Nasopharyngeal carcinoma Immunodeficient host: 淋巴细胞增殖性疾病 ;Microbiologic diagnosis 异嗜性抗体的检测—传染性单核细胞增多症的辅助诊断 EBV感染后非特异活化产生的IgM抗体，能非特异凝集牛、绵羊RBC，抗体滴度超过1：80有诊断意义