Minimum Information for High Content Screening (MIAHA)高内涵筛选的最小信息（miaha）.ppt

下载文档 降价啦

3
0
约7.98千字
约 23页
2020-07-16 发布于湖北
举报
版权申诉
保障服务

Minimum Information for High Content Screening (MIAHA)高内涵筛选的最小信息（miaha）.ppt

1、本文档共23页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。

Minimum Information for High Content Analysis(MIAHA) Mark Collins Ph.D Background Drive towards a standard for HCS data interchange More than just the image Meta data Cellomics (now ThermoFisher) has developed a set of Minimum Information guidelines for exchange of data between HCS platforms NOT a standard Walk through the minimum information Solicit input Hand this over to an independent body to create the standard Vendor neutral What is Minimum Information? Purpose To establish criteria by which HCS/HCA experiments may be recorded that provides enough detail to allow for correct interpretation and interchange of data NOT software, not XML, not code libraries These may come later Why Minimum Information for HCS? Standards drive innovationMultiple consumers and providers of information Minimum Information for High Content Analysis Five basic elements Experiment Sample Details Campaign Instrument Data Multiple elements Use clear ontologies A word on Ontologies Key to MInf Consistent vocabulary for descriptive elements (e.g cell types etc) MIAHA will use Ontology for Biomedical Investigation (OBI) FuGO (Functional Genomics Ontology) MeSH (medical subject headings – NLM) SNOMED NCBI Taxonomy We may agree our own terminology for HCA Cellomics has such an ontology we will share Ontology for HCA - excerpt The major elements of MIAHA Walk through the major elements of MIAHA Open for discussion Independent body should draft the MIAHA requirements We will hand over work so far Element: Experiment MIAHA defines that the following pieces of information shall be provided for the basic element Name Abstract Brief description of the experiment, purpose, rationale etc Keywords Ontology based keywords, e.g. Kinase, IL-1 Experiment variables Brief description of the variables that are being assessed, e.g. EGF treatment vs.control Project Name Description Owner Experimenter Name Address URL Email Address Organization Date Element: Sample Details MIAHA defines that the following