过渡金属催化芳香化合物碳氢键活化.ppt

Ortho-Carbonylation Fukuyama, T.; et al. J. Org. Chem. 1997, 62, 5647 Ortho-Silylation Kakiuchi, F.; et al. Chem. Lett. 2001, 422. Chem. Lett. 2002, 396 Kakiuchi, F.; et al. Chem. Lett. 1995, 681 Jia, C.; et al. Science 2000, 287, 1992 Kuninobu Y.; et al. Angew.Chem. Int. Ed. 2007, 46, 6518 Conclusion and Outlook Outstanding results have been obtained in selectivity and atom economy. These development will help both synthetic and material chemist a great deal Development of milder, lower temperature reaction conditions Fine-tuning of catalyst systems to allow for the industrial use Transition Metal-Catalyzed C-H Bond Activation of Aromatic Compounds：Chelation-Assisted Ortho-Functionalization Outline Introduction Catalytic Ortho-Functionalization Conclusion and Outlook Introduction Introduction Lewis, L. N.;Smith, J. F, J. Am. Chem. Soc. 1986, 108, 2728 Introduction Murai, S.; et al. Nature 1993, 366, 529 Introduction Advantages High selectivity Atom economy Clean and economical process Catalytic Ortho-Functionalization Ortho-Alkylation Ortho-Arylation Ortho-Carbonylation Others Ortho-Alkylation Jun, C. H. Angew.Chem. Int. Ed. 2000, 39, 3440 Ortho-Alkylation Ahrendt, K. A.; et al. Org. Lett. 2003, 5, 1301 Ortho-Alkylation Thalji, R. K.; et al. J. Am. Chem. Soc. 2004, 126, 7192 Ortho-Alkylation Chen X.; et al. J. Am. Chem. Soc. 2006, 128, 12634 Ortho-Arylation Ortho-Arylation Kakiuchi, F.; et al. J. Am. Chem. Soc. 2003, 125, 1698. J. Am. Chem. Soc. 2005, 127, 5936 Ortho-Arylation Kakiuchi, F.; et al. J. Am. Chem. Soc. 2005, 127, 5936 Ortho-Arylation Wan X. B., et al. J. Am. Chem. Soc. 2006, 128, 7416. Punna S, et al. Synlett 2004, 13, 2351. Rodriguez N.; et al. J. Org. Chem. 2004, 69, 8070. Shi Z J.; et al. Angew.Chem. Int. Ed. 2007, 46, 5554 Ortho-Arylation Ortho-Arylation Kalyani, D.; et al. J. Am. Chem. Soc. 2005, 127, 7330 Ortho-Arylation Ortho-Arylation Ortho-Arylation Ortho-Arylation Shabashov, D.; Daugulis, O. Org. Lett. 2005, 7, 3657 Ortho-Carbonylation