英文论文投稿信cover-letter模板.pdfVIP

英文论文投稿信 Cover letter 模板 Case 1 Dear Editor, We would like to submit the enclosed manuscript entitled GDNF Acutely Modulates Neuronal Excitability and A-type Potassium Cha nnels in Midbrain Dopaminergic Neurons, which we wish to be co nsidered for publication in Nature Neuroscience. GDNF has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic neurons, which are degenerat ed in Parkinson’s disease. In this paper, we report an unexpected, a cute effect of GDNF on A-type potassium channels, leading to a p otentiation of neuronal excitability, in the dopaminergic neurons in culture as well as in adult brain slices. Further, we show that GDN F regulates the K+ channels through a mechanism that involves acti vation of MAP kinase. Thus, this study has revealed, for the first t ime, an acute modulation of ion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survival factor for midbrain dopaminergic neurons, and suggest that the normal fun ction of GDNF is to regulate neuronal excitability, and consequentl y dopamine release. These results may also have implications in the treatment of Parkinson’s disease. Due to a direct competition and conflict of interest, we request that Drs. XXX of Harvard Univ., and YY of Yale Univ. not be conside red as reviewers. With thanks for your consideration, I am Sincerely yours, case2 Dear Editor, We would like to submit the enclosed manuscript entitled Ca2+-bi nding protein