肺部感染抗生素使用.ppt

Evaluation only. Created with Aspose.Slides for .NET 4.0 Client Profile 17.1. Copyright 2004-2017Aspose Pty Ltd. Evaluation only. Created with Aspose.Slides for .NET 4.0 Client Profile 17.1. Copyright 2004-2017Aspose Pty Ltd. 肺部感染的抗生素使用 200级呼吸治疗专业 王元元 Evaluadon onr. ith Aspose slides for NET 4o client P Evaluation only. Created with Aspose Slides for NET 4.0 Client Profile 171 Copyright 2004 -2017 Aspose Pty Ltd  Evaluation only. Created with Aspose.Slides for .NET 4.0 Client Profile 17.1. Copyright 2004-2017Aspose Pty Ltd. Evaluation only. Created with Aspose.Slides for .NET 4.0 Client Profile 17.1. Copyright 2004-2017Aspose Pty Ltd. 抗菌药物及其作用机制 抗菌作用主要是干扰病原菌的生化代谢过程,从 而影响其结构与功能,致使其失去生长繁殖力而 而到抑制或杀灭病原菌的作用。 )抑制细胞细胞壁的合成 二)影响胞浆膜的通透性 三)影响胞浆内生命物质的合成,主要是核酸 和蛋白质。 Evaluadon onr. ith Aspose slides for NET 4o client P Evaluation only. Created with Aspose Slides for NET 4.0 Client Profile 171 Copyright 2004 -2017 Aspose Pty Ltd  Evaluation only. Created with Aspose.Slides for .NET 4.0 Client Profile 17.1. Copyright 2004-2017Aspose Pty Ltd. Evaluation only. Created with Aspose.Slides for .NET 4.0 Client Profile 17.1. Copyright 2004-2017Aspose Pty Ltd. 细菌对抗菌药物的耐药性 ●细菌产生灭活抗菌药物的酶 ●细菌体内抗菌药原始靶位结构改变 ●细菌胞浆膜通透性发生改变 ●细菌代谢途径的改变 Evaluadon onr. ith Aspose slides for NET 4o client P Evaluation only. Created with Aspose Slides for NET 4.0 Client Profile 171 Copyright 2004 -2017 Aspose Pty Ltd  Evaluation only. Created with Aspose.Slides for .NET 4.0 Client Profile 17.1. Copyright 2004-2017Aspose Pty Ltd. Evaluation only. Created with Aspose.Slides for .NET 4.0 Client Profile 17.1. Copyright 2004-2017Aspose Pty Ltd. 抗菌药物的药代动力学/药效学 剂量 药动学 药效学 起效 ●溶解 时间依赖杀菌细菌数量 ●吸收 浓度依赖杀菌·死亡率 ●分布 抗生素后效应·症状和体征的识别 ●代谢 抗菌药物在体内的作用主要决定于药 ●排泄 动力学和MIC MIC Total Pharmacodynamics in Theory and Practice. 1st ed. New York, NY: Marcel Dekker:/ose PG,eds. Antimicrobial Dudley MN, Griffith D. Animal models of infection. In: Nightingale CH Evaluadon onr. ith Aspose s