基础免疫学基础免疫学1Cell Adhesion Molecules and Their Roles and Regulation in the Immune and Tumor Microenvironment.pdf

REVIEW published: 22 May 2019 doi: 10.3389/fimmu.2019.01078 Cell Adhesion Molecules and Their Roles and Regulation in the Immune and Tumor Microenvironment HeidiHarjunpää,MarcLlortAsens,CarlaGuentherandSusannaC.Fagerholm* Research Program of Molecular and Integrative Biosciences, Faculty of Bio- and Environmental Sciences, University of Helsinki, Helsinki, Finland The immune system and cancer have a complex relationship with the immune system playing a dual role in tumor development. The effector cells of the immune system can recognize and kill malignant cells while immune system-mediated inflammation can also promote tumor growth and regulatory cells suppress the anti-tumor responses. In the center of all anti-tumor responses is the ability of the immune cells to migrate to the tumor site and to interact with each other and with the malignant cells. Cell adhesion molecules including receptors of the immunoglobulin superfamily and integrins are of crucial importance in mediating these pro