基础免疫学基础免疫学1rom defense of the single cell to guardian of the intravascular space.pdf

基础免疫学基础免疫学1rom defense of the single cell to guardian of the intravascular space.pdf

  1. 1、本文档共17页,可阅读全部内容。
  2. 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
  3. 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载
  4. 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
查看更多
HHS Public Access Author manuscript A Immunol Rev. Author manuscript; available in PMC 2017 November 01. u t h Published in final edited form as: o r Immunol Rev. 2016 November ; 274(1): 9–15. doi:10.1111/imr.12474. M a n u s c Evolution of the complement system: from defense of the single r i p t cell to guardian of the intravascular space Michelle Elvington, M. Kathryn Liszewski, and John P. Atkinson Department of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, Saint Louis, MO 63110, USA A u Abstract t h o The complement system is an evolutionarily ancient component of immunity that revolves around r M the central component C3. With the recent description of intracellular C3 stores in many types of a human cells, our view of the complement system has expanded. In this article, we hypothesize that n u s a primitive version of C3 comprised the first element of the original complement system and c r initially functioned intracellularly and on the membrane of single-cell organisms. With increasing i p t specialization and multicellularity, C3 evolved a secretory capacity that allowed it to play a protective role in the interstitial space. Upon development of a pumped circulatory system, C3 was synthesized in large amounts and secreted by the liver to protect the intravascular space. Recent discoveries of intracellular C3 activation, a C3-based recycling pathway and C3 being a driver and programmer of cell metabolism suggest that the complement system utilizes C3 to guard not only extracellular but als

文档评论(0)

恬淡虚无 + 关注
实名认证
内容提供者

学高为师,身正为范.师者,传道授业解惑也。做一个有理想,有道德,有思想,有文化,有信念的人。 学无止境:活到老,学到老!有缘学习更多关注桃报:奉献教育,点店铺。

1亿VIP精品文档

相关文档