基础免疫学基础免疫学1 immune homeostasis_ Crosstalk between dendritic cells, macrophages and B-cells.pdf

Submit a Manuscript: /esps/ World J Gastroenterol 2014 August 7; 20(29): 9653-9664 Help Desk: /esps/helpdesk.aspx ISSN 1007-9327 (print) ISSN 2219-2840 (online) DOI: 10.3748/wjg.v20.i29.9653 © 2014 Baishideng Publishing Group Inc. All rights reserved. TOPIC HIGHLIGHT th WJG 20 Anniversary Special Issues (3): Inflammatory bowel disease Intestinal antigen-presenting cells in mucosal immune homeostasis: Crosstalk between dendritic cells, macrophages and B-cells Elizabeth R Mann, Xuhang Li Elizabeth R Mann, Xuhang Li, Division of Gastroenterology, Here, we review the role of all three types of APC in Department of Medicine, The Johns Hopkins University School intestinal immunity, both in the steady state and in of Medicine, Baltimore, MD 21205, United States inflammation, and how these cells interact with one an- Author contributions: All the authors contributed equally to other, as well as with the intestinal microenvironment, this manuscript. to shape mucosal immune responses. We describe Correspondence to: Xuhang Li, PhD, Division of Gastroenter- mechanisms of maintaining intestinal immune tolerance ology, Department of Medicine, The Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross Research Bldg Rm in the steady state but also inappropriate responses of 746, Baltimore, MD 21205, United States. xuhang@ APC to components of the gut microbiota that contrib- Telephone: +1-443-2874804 Fax: +1-410-9559677 ute to pathology in IBD. Received: October 19, 2013 Revised: February 26, 2014 Accepted: April 27, 2