高强度聚焦超声消融兔腹主动脉旁肝肿瘤的安全性和有效性.pdf

中国肿瘤临床2014年第41卷第23期 Chin J Clin Oncol 2014,Vol.41,No.23 1517 高强度聚焦超声消融兔腹主动脉旁肝肿瘤的 安全性和有效性* 税 莲 何 敏 刘映江 龚春梅 张 炼 观察高强度聚焦超声消融兔腹主动脉旁肝肿瘤后肝肿瘤剂量学、磁共振图像、病理学及生存期影响，评价HIFU 摘要 目的： 消融兔腹主动脉旁肝肿瘤安全性和有效性。 分别于HIFU组（32只）和对照组（20只）实验兔建立腹主动脉旁的VX2肝肿瘤 方法： 模型，HIFU组瘤兔于MR引导的高强度聚焦超声消融肿瘤，分析腹主动脉旁肿瘤消融剂量学，MR观察消融前后肿瘤影像学变化， 病理学观察肿瘤消融后坏死情况，对比观察HIFU组与对照组瘤兔生存期。 MRI和病理学均表明MR引导下HIFU能完全消 结果： 3 融兔腹主动脉旁VX2肝肿瘤，EEF为25.72±11.40J/mm HIFU组的生存期明显高于对照组，差异具有统计学意义（P<0.05）。结 HIFU能安全有效消融兔腹主动脉旁VX2肝肿瘤并且能明显提高存活期。 论： 关键词 高强度聚焦超声 兔 腹主动脉 肝脏肿瘤 磁共振 doi:10.3969/j.issn.1000-8179 Safety and effectiveness of high-intensity focused ultrasound ablation for liver tumor adjacent to rabbit abdominal aorta Lian SHUI, Min HE, Yingjiang LIU, Chunmei GONG, Lian ZHANG Correspondence to: Lian ZHANG; E-mail: lianwzhang@ State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and the Ministry of Science and Technology, College of Biomedical Engineering, Chongqing Key Laboratory of Biomedical Engineering;Chongqing Medical University This work was supported by the National Key Basic Research and Development Plan (No.2011CB707900) ,The National Science & Technology Pillar Program during the Twelfth Five-year Plan Period (No.2011BAI 14B01 ）and the Chongqing Natural Science Foundation （No. cstc2013jcyjA 10109, cstc2011jjA 10033, cstc2012jjA 10083) Abstract Objective: To evaluate the safety and efficacy of high-intensity focused ultrasound (HIFU) ablation for the VX2 liver tumor near the hepatic main blood vessels of rabbits by using dosimetry and magnetic r