全面调节性B细胞.pptVIP

Bregs in autoimmunity——EAE B-cell-deficient mice (mMT) failed to control EAE, and unlike the wild-type mice, did not undergo spontaneous remission In the absence of IL-10 production by B cells, the pro- inflammatory type 1 immune response persisted and mice did not recover Lack of disease resolution was attributed to the inability of T cells to switch to a protective Th2 response 课件 Bregs in autoimmunity——IBD mMT TCRa-/- mice manifest an earlier onset of disease and an exacerbated intestinal in?ammation compared with the TCRa-/-mice The amelioration of disease was paralleled by an increa